Hydroxychloroquine Versus Placebo in Primary Sjögren's Syndrome

Inclusion criteria: * Patients suffering from primary Sjögren's syndrome according to the European-American consensus group criteria * Male and female aged of 18 or more * Conducting a clinical examination beforehand. * Having undergone less than 6 months before an ophthalmological examination, which did not counter-indicated hydroxychloroquine. * Patient without heart conduction disturbance (PR\>=0.2 sec and QRS\>=0.08 sec). * Patient with the ability to give informed, dated and signed consent before the beginning of any proceedings related to the trial * Patients treated with corticosteroids and / or NSAIDs, and / or cyclosporine, and / or pilocarpine must have received stable doses of these treatments during the month preceding inclusion. Exclusion criteria: * SJ associated with other autoimmune diseases * Retinopathy /severe cataract/ monophthalmos * Previous or ongoing treatment by hydroxychloroquine * Treatment by another immunosuppressant not interrupted at least 4 weeks prior to inclusion, or 6 months prior to inclusion for cyclophosphamide or rituximab * lymphoma or other severe SJp complications: vasculitis responsible for a documented renal, neurological, digestive or heart involvement, glomerular disease associated with hematuria and / or proteinuria \> 0.5 g / d), CNS involvement, peripheral neurological involvement with motor deficiency scored at 3 or less on a scale of 5 , interstitial pneumonitis, recent symptomatic cryoglobulinemia with neurological, renal, or other systemic involvement, myositis with motor deficiency (isolated purpura is not an exclusion criteria) * Chronic Alcoholism * Hepato-cellular insufficiency * Creatinine clearance \<60 ml / min * Risk of lost follow-up * People younger than 18, major trusteeship and guardianship, or deprived of liberty * Pregnancy /Breastfeeding * Hypersensitivity to chloroquine or to hydroxychloroquine or any of the other constituents of Plaquenil * Psoriasis or intermittent porphyria. * G6PD deficiency, congenital galactosemia, malabsorption syndrome, glucose and galactose, or lactase deficiency. * Non-membership in a social security system.