Fatigue is one of the most frequently observed symptoms for company workers, and oxidative stress is regarded as one of its cause. Vitamin C is a well-known antioxidant, and the investigators seek for evidence of the efficacy of high dose vitamin C parenteral supplement on fatigue symptoms of company workers after work.
Previous studies dealing with vitamin C were focusing on terminal cancer patients or those with chronic fatigue syndrome. Since used drug dosage and the ways of administering vitamin C were not identical, the results were not consistent throughout those studies. This study is aimed to evaluate the efficacy of high dose vitamin C with parenteral supplement on relieving fatigue for apparently healthy volunteers.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
TRIPLE
Enrollment
150
Single intravenous injection of vitamin C 10g(20ml) with 100ml of normal saline over 30 minutes
Single intravenous injection of 120ml of normal saline over 30 minutes
DongGuk University International Hospital
Goyang-si, Gyeonggi-do, South Korea
Degree of fatigue at the point of time with visual analogue scale from 0 to 10
Time frame: Before intravenous vitamin C injection and right after completing injections, and one day later
Reactive oxygen species
Time frame: Before intravenous vitamin C injections, right after completing injections, and one day later
Plasma vitamin C level
Time frame: Before intravenous vitamin C injections and right after completing injections
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