Hereditary Colorectal and Associated Tumor Registry Study

Inclusion Criteria: * Identified gene mutation * Personal history of colorectal cancer diagnosed ≤ 50 * Personal history of cancer with tumor studies suggestive of Lynch syndrome * Personal history of multiple primary tumors associated with a hereditary cancer syndrome (colorectal, uterus, stomach, ovary, small bowel, hepatobiliary tract, transitional cell carcinoma of the renal pelvis/ureter, brain) * Personal history of one of the above cancers and a family history of one or more of the above cancers * Personal or family history of diffuse gastric cancer * From a known genetic predisposition family * Personal history of \> 10 colon adenomas (cumulative over a lifetime) * Personal history of any number of hamartomatous polyps * Personal history of multiple large (\> 1cm) serrated polyps to right of sigmoid Exclusion critera: * Individuals under the age of 8 * Individuals who cannot travel to Pittsburgh for in-person enrollment * Individuals who cannot provide informed consent