Clinical Assessment of Fish Oil-based Lipid Emulsion Infusions in Critical Patients With Severe Sepsis

Inclusion Criteria: * Patients admitted to Li Shin Hospital's ICU with a main diagnosis of severe sepsis. Exclusion Criteria: * Age of ﹤15 years * Pregnancy * Patients treated with immunosuppressive drugs or the equivalent of hydrocortisone more than 300 mg daily * Plasma triglyceride concentration of more than 400 mg/dl * Infection with human immunodeficiency virus * Anticipated rapid fatality from irreversible underlying disease or malignancy * Severe hemorrhagic disorders * Acute myocardial infarction * Recent stroke (within 3 month) * Suspected or proven pulmonary embolism * Cirrhotic liver and/or acute hepatitis ( elevation of serum GOT or GPT \> 5 times of normal upper limit) * Chronic renal failure (Cr \>3.5 mg/dl upon admission) or end stage of renal diseases * Allergic reactions against fish or egg proteins.