Comparison Between Effect of Acetazolamide and NaHco3 in Prevention of Contrast Nephropathy

Shiraz University of Medical Sciences240 enrolled

Overview

The purpose of this study is whether Acetazolamide is effective in prevention of contrast nephropathy

Contrast induced nephropathy is one of common causes of acute renal failure many preventive protocol existed . 240 patient that underwent coronary angiography randomly divided in three groups.Group 1,2,3 will receive Bicarbonate ,Acetazolamide+Normal salin and Normal salin respectively.We compare prevalence of contrast nephropathy in each group.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

240

Conditions

Contrast Induced Nephropathy

Interventions

sodium bicarbonateDRUG

150 meq/l Sodium bicarbonate 3cc/kg/hr before and 1cc/kg/hr after angiography

AcetazolamideDRUG

Acetazolamide 250 mg+ 1 cc/kg/hr normal salin before and after angiography

normal salinDRUG

1 cc/kg/hr 6 hour before and after angiography

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * patient that underwent coronary angiography Exclusion Criteria: * serum Cr. more than 3 mg/dl * electrolyte and acid-base imbalance * pulmonary edema * allergy to Acetazolamide

Locations (1)

Fars Heart Foundation , Kowsar hospital

Shiraz, Iran

Outcomes

Primary Outcomes

Increased base line creatinine at least 25%

Time frame: 24 hr later

Data from ClinicalTrials.gov

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