Investigation of a Novel Positive Pressure Therapy to Rescue Patients Failing to Tolerate CPAP During an Initial Encounter

Inclusion Criterion: 1. Age 21-75 2. New Diagnosis of OSA with a baseline RDI ≥ 15 events/hr of sleep determined by either full night or split night PSG 3. Able and willing to provide written informed consent 4. Able to follow study procedures 5. Sub-optimal PSG titration with at least 3 hours of attempted PAP titration (defined below): and deemed by their physician as a titration failure Sub-optimal PSG titration: at least one of the following: 1. Poor sleep efficiency during titration period (sleep efficiency ≤ 70%) (participants may be on sleep medications as per standard lab CPAP protocol ) or; 2. Frequent arousals based on three seconds of alpha frequency on EEG (non PLM-related) of 20 or greater per hour during the titration portion of the study or; 3. CPAP titration aborted due to participant's request (due to intolerance), or 4. Persistent sleep disruption despite therapeutic CPAP therapy and in the judgment of the reviewing physician, suggesting a low probability to CPAP adherence Exclusion Criterion: 1. Participation in another interventional research study within the last 30 days 2. Major uncontrolled medical or psychiatric condition such as congestive heart failure, neuromuscular disease, renal failure etc. 3. Prior CPAP or Bi-Level PAP use (within last 2 years) 4. Chronic respiratory failure or insufficiency, moderate COPD (FEV1 \< 60%), or any known condition of an elevation of arterial carbon dioxide levels while awake 5. Surgery of the upper airway, nose, sinus, or middle ear within the previous 90 days 6. Presence of an untreated, diagnosable, non-OSA related sleep disorder (e.g. restless legs syndrome, insomnia, etc.) 7. Periodic Limb movement arousal index of 10 or greater. 8. Refusal to consider further interventions to standard CPAP to optimize positive pressure therapy (e.g. different mask than what was used in lab) 9. PAP therapy otherwise medically complicated or contraindicated such as those with a difficult to size or adjust interface (mask) resulting in facial pain, skin irritation or trauma, or excessive air leaks 10. Shift workers or people experiencing jet lag 11. Known history of alcohol and or drug abuse 12. Diagnosis of Complex Sleep Apnea, (appears to be classic obstructive or mixed sleep apnea, but exhibits disruptive central apneas and periodic breathing on CPAP) 11, 12 or persistent central apnea during diagnostic PSG. 13. Diagnosis of Attention Deficit Hyperactivity Disorder 14. Chronic Hypnotic use (nightly use for three months or less)