RATIONALE: Monoclonal antibodies, such as CP-751871, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. PURPOSE: This phase I trial is studying the side effects and best way to give CP-751871 in treating patients with early-stage breast cancer that can be removed by surgery.
Primary * To evaluate the change in total tumor choline levels in women with operable early breast cancer in response to neoadjuvant CP-751871 treatment. Secondary * To assess changes in tumor glucose levels after CP-751871 treatment using magnetic resonance spectroscopy in these patients. * To assess the safety, tolerability, and immunogenicity of CP-751871 in these patients. * To assess the effect of CP-751871 on Insulin-like Growth Factor 1 receptor (IGF-1R) signaling markers in tumor tissues in these patients. * To assess the clinical efficacy of CP-751871 in these patients (MRI and pathological responses). OUTLINE: Patients receive CP-751871 IV over 5 hours on days 1 and 22 and undergo magnetic resonance spectroscopy on days 8 and 29. Patients may also undergo surgery between days 29-43 to obtain a tumor sample for analysis of markers related to the IGR-1R pathway. After completion of study treatment, patients will be followed for 5 months.
Study Type
INTERVENTIONAL
Purpose
TREATMENT
Masking
NONE
Tumor total choline (tCho) changes determined by magnetic resonance spectroscopy
Safety, tolerability and human anti-human antibodies (HAHA) response
Tissue markers
Measure of tumor glucose levels
Pathological response
Tumor size by MRI
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.