Effect of Whey Protein Supplementation and Resistance Exercise on Muscle Parameters in Older Adults

Tufts University80 enrolled

Overview

This research study is looking at the effects of a whey protein nutritional supplement on changes in muscle mass, strength and physical function in response to a 6 month program of strength training exercise.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Mobility Limitation

Interventions

Whey proteinDIETARY_SUPPLEMENT

powdered, 46g supplement dissolved in fluids, twice daily

Maltodextrin placeboDIETARY_SUPPLEMENT

powdered, 46g supplement dissolved in fluids, twice daily

Eligibility

Sex: ALLMin age: 70 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male and Females 70-85 yrs * Community dwelling * Short Physical Performance Battery score \< 10 * BMI = 21-32.5 Exclusion Criteria: * Acute or terminal illness * Mini Mental State Exam \< 23 * Myocardial infarction in previous 6 months, symptomatic coronary artery disease, or congestive heart failure * Upper or lower extremity fracture in previous 6 months * Uncontrolled hypertension (\>150/90 mm Hg). * Neuromuscular diseases and drugs which affect neuromuscular function. * Hormone replacement therapy * eGFR \<30 mL/min/1.73m2 * Types I and II Diabetes Mellitus * Dietary protein intake \< 0.8 g.kg-1.day-1 * Disorders of nutrient absorption * Milk, or whey allergy * Sulfa drugs and allergy to PABA-containing sunscreens

Locations (1)

Jean Mayer USDA Human Nutrition Research Center on Aging

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

1 Repetition Maximum Muscle Strength 1-RM (N) Double Leg Press

The maximum muscle strength of the leg extensor muscles as measured by pneumatic strength training equipment.

Time frame: Baseline and follow up (6 months)

Secondary Outcomes

Lean Mass

Whole body lean mass (kg) as measured by dual energy x-ray absorptiometry.

Time frame: Baseline and follow up (6 months)

Data from ClinicalTrials.gov

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