Botulism Antitoxin Effects on Paralysis Induced by Botulinum Neurotoxins in the EDB Muscle

Inclusion Criteria: * Male or female * Age 18 - 55 years * Body-mass index 19-30 * Normal and healthy as determined by medical history, physical examination, ECG, NCS, vital signs and tests of liver, kidney and hematological functions * Adequate form of contraception for female subjects * For women with child-bearing potential-using hormonal contraception (oral, injectable or implant) continuously for 3 months prior to the start of the study and willing to continue to use hormonal contraception throughout the entire study. IUD inserted or use of condoms for at least 2 months prior to dosing * Other forms of contraception may be considered as adequate at physician's discretion * Surgically-sterilized female subjects * For female subjects who are postmenopausal, an FSH ≥ than 40 mIU/mL must be obtained. If the FSH is \< 40 mIU/mL the subject must agree to use an acceptable form of contraception (see above for acceptable forms of contraception) * Signed written Informed Consent Exclusion Criteria: * Previously injected with BOTOX®, BOTOX® COSMETIC or MYOBLOC® * Any known or documented Botulinum infection/intoxication * Any known or documented allergies to horses (e.g. rash, wheezing, rhinitis etc. after exposure to horses) * Any known or documented allergies to horse serum (observation of adverse events after treatment with any kind of product containing horse serum) * Any moderate or severe food allergies, seasonal allergies or hay fever requiring treatment with peroral or parenteral immunosuppressive drug * Any known or documented hypersensitivity to blood products derived from a human or equine source * Any known or documented hypersensitivity to albumin * Positive result for Botulism Antitoxin skin sensitivity testing * Any known or documented allergy to rubber, latex or plastic * Known acute or chronic moderate or severe asthma requiring treatment with peroral and / or parenteral immunosuppressive drugs * Previously diagnosed or currently suspected Multiple Sclerosis or other neuromuscular degenerative disorder * Previously diagnosed or currently suspected motor neuron disease * Previously or currently diagnosed peripheral neuropathy of lower extremities' nerves * Current infection of the skin / skin problems at the injection site (foot) * Scar tissue or tattoo of the skin over the extensor digitorum brevis muscles. * Previously diagnosed or currently suspected diabetes * Previously diagnosed or currently suspected coagulopathies * Previously diagnosed or currently suspected vasculitis * Current treatment or treatment in the past 7 days with aminoglycosides, clindamycin, quinolines or aminopyridine * Heavy smokers (\>10 cigarettes/day) * History of, or suspected substance abuse (including alcohol) or failure of drug screen at screening or at baseline * Use of any investigational product within the past 30 days (prior to screening) * Pregnancy or lactation * Positive serological test for diagnosis of HIV infection, HBV hepatitis, or HCV hepatitis * Abnormal (based on principle investigator assessment) nerve conduction study (NCS) results