Clinical Study Investigating the Effect of Sodium Nitroprusside Infusion on Thyroidal Function

Kavaklıdere Umut Hospital106 enrolled

Overview

Whether use of SNP during cardiac surgery has any effect on thyroid function has not yet been investigated in humans. The aim of this study was to investigate the effects of SNP administration during the rewarming period of cardiac operations on circulating levels of thyroid hormones.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SCREENING

Masking

SINGLE

Enrollment

106

Conditions

Nitroprusside Thyroid Hormones

Interventions

sodium nitroprussideDRUG

sodium nitroprusside infusion at 1 microgram/kg/min dose during rewarming period of cardiac operations

placeboDRUG

placebo

Eligibility

Sex: ALLMin age: 30 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: Patients without history of: * thyroidal disease * hypertension * pulmonary disease * peripheral vascular disease * stroke * recent myocardial infarction within the week prior to operation * unstable angina pectoris * liver or kidney dysfunction * morbid obesity * cachexia * sulfonylurea intake Exclusion Criteria: * Patients who needed positive inotropic pharmacologic support during or after the operation * Patients who developed atrial fibrillation in the post operative period requiring amiodarone therapy * In addition, patients receiving any medication known to interfere with any step of thyroid hormone metabolism such as * amiodarone * propranolol * furosemide * non-steroidal anti-inflammatory agents * steroids * estrogens * antacids * diphenylhydantoin * spironolactone

Locations (1)

Kavaklıdere Umut Hastanesi

Ankara, Turkey (Türkiye)

RECRUITING

Outcomes

Primary Outcomes

free T3

Time frame: on admission, prior to operation, at the beginning of CPB, following CPB, at first, third and fifth postoperative days

Secondary Outcomes

total T3

Time frame: on admission, prior to operation, at the beginning of CPB, following CPB, on the first, third and fifth postoperative days

Central Contacts

alp aslan, md

CONTACT

0905425179917 alpslan@yahoo.com

Data from ClinicalTrials.gov

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