Diagnosis and Therapy of Vulnerable Atherosclerotic Plaque

Aristotle University Of Thessaloniki300 enrolled

Overview

The aim of the present study is to examine the atherosclerotic plaque stability using in vivo and in vitro techniques and to investigate the influence of exercise, anti-diabetic, lipid-lowering and cannabinoids receptor antagonists on atherosclerotic plaque texture in patients with cardiovascular risk and animals prone to atherosclerosis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Enrollment

300

Conditions

Carotid Atherosclerosis Stroke Type 2 Diabetes Metabolic Syndrome

Interventions

atorvastatinDRUG

A:Experimental study of atherosclerosis B1:Effects of exercise on experimental atherosclerosis B2:Effects of exercise on high risk patients C1:Effects of statins on atherosclerotic plaque stability (experimental) C2:Effects of statins on atherosclerotic plaque stability (clinical) D:Effects of rosiglitazone and metformin on cardiovascular risk factors E:Effects of rimonabant on atherosclerotic plaque stability (experimental)

rimonabantDRUG

rosiglitazone

Eligibility

Sex: ALLMin age: 50 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Carotid atherosclerosis * Femoral atherosclerosis * Cardiovascular risk Exclusion Criteria: * Heart failure * Renal disease * Liver disease * Life-threatening diseases

Locations (1)

General Hospital of Thessaloniki "Hippokratio"

Thessaloniki, Greece

Outcomes

Primary Outcomes

Ultrasound and immunohistochemical parameters of plaque stability; novel cardiovascular risk factors

Time frame: 3 years

Secondary Outcomes

Long-term cardiovascular outcomes

Time frame: 3 years

Data from ClinicalTrials.gov

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