The proposed study will focus on anesthesia and anesthesia-induced hypotension as a possible cause for postoperative fluid retention and hyponatremia, and investigate gender differences in this response.
30 healthy women and 30 healthy men, who are scheduled for surgery of the middle ear or parotic gland are included in the study. Within each gender group, the subjects are randomized to receive perioperative intravenous fluid regimes either based on body weight or lean body mass (LBM). The surgery lasts for at least 3 hours, the intervention period (fluid administration according to protocol) will last 10-12 hours, the study period will be 20-24 hours. Blood samples for analysis of plasma sodium, potassium, glucose and osmolality are collected preoperatively and the following morning together with analysis of urine produced during the study period.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
60
Preoperative: bolus of 10 ml/kg body weight. During operation: 5 ml/kg body weight/hr. Postoperative: 3 ml/kg body weight/hr
Preoperative: bolus of 12 ml/kg LBM. During operation: 6 ml/kg LBM/hr. Postoperative: 3.5 ml/kg LBM/hr
Department of Anesthesia and Intensive Care, Karolinska University Hospital Huddinge
Stockholm, Stockholm County, Sweden
RECRUITINGDept of Anaesthesia and Intensive Care, Kalmar County Hospital
Kalmar, Sweden
NOT_YET_RECRUITINGDepartment of Anaesthesia and Operation
Linköping, Sweden
Change between preoperative and postoperative plasma sodium concentration
Time frame: 24 hrs
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Dept. of Anesthesiology and Intensive Care, Karolinska University Hospital, Solna
Stockholm, Sweden
RECRUITINGDept of Anaesthesia and Intensive Care, Uppsala University Hospital
Uppsala, Sweden
TERMINATED