Cranberry Juice in the Prevention of Urinary Tract Infections in Children

University of Oulu262 enrolled

Overview

The objective of the study is to determine whether recurrences of urinary tract infection in children can be prevented with cranberry juice.

Five percent of children have at least one UTI episode and 30% of these episodes recur. Recurrences and the risk of renal damage are indications for long term antimicrobial prophylaxis, but emerging antimicrobial resistance underlines the need for alternatives. The bacteria causing urinary tract infection arise from the stools. Dietary changes can alter the balance of faecal bacteria. Vaccinium berries and products containing lactobacilli have been shown to act against the coliform bacteria that cause most urinary tract infections. In our previous study cranberry juice was effective in preventing symptomatic recurrences of urinary tract infections in women. The objective of our study is to determine whether recurrences of urinary tract infection in children can be prevented with cranberry juice.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

262

Conditions

Urinary Tract Infections

Interventions

Cranberry juiceBIOLOGICAL

5 ml/kg up to 300 ml, 1-2 doses daily for six months

Placebo juiceBIOLOGICAL

5 ml/kg up to 300 ml, 1-2 doses daily for six months

Eligibility

Sex: ALLMin age: 1 YearMax age: 16 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Urinary Tract Infection 0-2 months priorly Exclusion Criteria: * Antibiotic Prophylaxis

Locations (1)

University of Oulu

Oulu, Finland

Outcomes

Primary Outcomes

Occurrence of the first recurrence

Time frame: 12 months

Secondary Outcomes

Total number of UTI episodes and use of antimicrobials

Time frame: 12 months

Data from ClinicalTrials.gov

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