This study is designed to evaluate whether or not oral viscous budesonide is effective in treating children with Eosinophilic Esophagitis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
32
Budesonide is taken daily for three months. In addition, Prevacid is taken twice daily for three months.
Placebo is taken daily for three months. In addition, Prevacid is taken twice daily for three months.
Rady Children's Hospital, San Diego
San Diego, California, United States
Number of Participants With Improvement of Espohageal Eosinophilia
Repeat endoscopy was undertaken using the Olympus P160 endoscope (by RD) at 3 months of treatment.
Time frame: 3 Months
Upper Gastrointestinal Endoscopy Score
Endoscopy scoring tool took into account the following categories: Mucosal pallor/reduced vasculature Linear furrows/mucosal thickening White plaques Concentric rings/stricture Friability/"tissue-paper" mucosa Histology scoring tools Epithelial histology score Peak eosinophil count Each category could score 0-3 for a total maximum score of 15. The higher the score the worse the disease.
Time frame: Baseline and 3 Months
Symptom Score
Total score was based on the following symptoms: Heartburn/regurgitation Abdominal pain Nausea/vomiting Anorexia/early satiety Dysphagia Symptom induced nocturnal wakening Gastrointestinal bleeding Each symptom could score 0-2 for a maximum score for 14 points. The lower the score the milder the symptoms and the higher the score the more severe symptoms.
Time frame: Baseline and 3 Months
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