Efficacy and Safety of Cetirizine Tablets Versus Ketotifen Dry Syrup in Children With Perennial Allergic Rhinitis

Inclusion Criteria: * had at least one of the 3 symptoms: sneezing, nasal discharge or nasal congestion; * severity of nasal symptoms was moderate to severe during the observation period; * criteria for allergic etiology of the disease fulfilled, i.e., positive IgE antibody test and positive eosinophil count in nasal discharge. Exclusion Criteria: * history of hypersensitivity to the ingredients of cetirizine or ketotifen formulation or to hydroxyzine; * history of drug hypersensitivity; * history of convulsive disorder; * vasomotor rhinitis or eosinophilic rhinitis; * asthma requiring treatment with adrenocortical hormones; * concomitant diseases which could impede the efficacy evaluation of the study drug; * subjects in the ascending-dose phase of hyposensitization therapy or non-modular therapy and who had not received the maintenance dosage; * pollen allergy; * malignant neoplasm.