Transplantation of Pancreatic Islets in Patients With Type 1 Diabetes Mellitus and Functional Kidney Graft

Inclusion Criteria: * Type 1 diabetes mellitus * Disease duration \> 5 years * ketose antecedents * Basal and stimulated plasma C-\< 0.2 ng/ml,\<0.06 nmol/l (glycemia must be measured simultaneously\_ 1.20 g/l or 6.6 mM, stimulation with glucagon IV 1 mg -Measured at à T0 and T 6 min) * Established kidney graft ≥ 6 months * Current creatinine clearance: ≥ 50 ml/min/1.73 m² and Proteinuria \< 0.5 g/24h * HbA1C\< 12% Exclusion Criteria: * Hemostasis problems * Documented hepatic pathology * Patient under 18 or over 65 year-old * Women with body weight over 70 kg (tolerance of 2 kg between inclusion day and transplantation day) or BMI \> 26 * Men with body weight \> 75 kg (tolerance of 3 kg between inclusion day and transplantation day) or BMI \> 26 * insuline needs \> 0.7 U/kg/j or 50 U/j * Serious life-threatening pathology * untreated hyperlipidemia * Hypersensitivity to drugs rapamycine-alike * Liver disease (transaminases or total bilirubin ≥ 3N) * Failure to communicate or cooperate with the investigator Exclusion criteria that are specific to the use of Rapamycine * Hypercholesterolemia (\> 350mg/dl, 9,1 mmol/l) not controlled * Hypertriglyceridemia (\> 500 mg/dl, 5,6 mmol/l) not controlled * Leukocytes \> 4500 /mm3 , neutrophils \> 2000/ mm3, platelets \> 100000/ mm3 * Any clinical or biological pathology that could interfere with the study * Past or present neoplasia (with the exception of non melanoma skin cancers) * Any hemostasis disorder needing a prolonged treatment with anticoagulation drugs. Low-dose aspirin is permitted. * Pregnancy, lactation, pregnancy project or absence of efficient contraception * Any medical or psychosocial condition susceptible to interfere with the study, such as drug abuse or recent alcohol abuse