Comparing Angioplasty and DES in the Treatment of Subjects With Ischemic Infrapopliteal Arterial Disease

Inclusion Criteria: * Subject must be \>= 18 and \<= 85 years old; * Female of childbearing potential must have a negative pregnancy test within 10 days prior to index procedure and utilize reliable birth control until completion of the 12-month angiographic evaluation; * Clinical diagnosis of symptomatic critical limb ischemia as defined by Rutherford 3, 4, or 5; * Single treatment of de novo or restenotic (after PTA only) lesion(s) in the tibioperoneal trunk, anterior and/or posterior tibial and/or peroneal artery; * A maximum of 2 vessels in 1 limb may be treated in the study, each vessel for only 1 target lesion, resulting in at single risk target lesion(s); In case 1 target lesion is located in the Tibioperoneal trunk, the 2nd target lesion (if applicable) can only be located in the anterior tibial artery; Additional non-target lesion(s) in remaining non-target vessel(s) can be treated at the physician's discretion by means of balloon dilation (± bail-out stenting); * The sum of the total length of both target lesions can be maximum 120 mm; * In total a maximum of 4 stents may be implanted to fully cover the maximum of 2 target lesions per subject; * Target vessel is \>= 2.5 and \<= 3.5 mm in diameter (visual estimate); * Target lesion stenosis is \>70% diameter stenosis (visual estimate); * Guidewire must be across the first (if applicable) target lesion and located intraluminally within the distal vessel before study randomization; * Willing to comply with the specified follow-up evaluation; * Written informed consent prior to any study procedures. Exclusion Criteria: * Significant (\>50%) stenoses distal to the target lesion that might require revascularization, or impede runoff; * Angiographic evidence of thrombus within target vessel; * Thrombolysis within 72 hours prior to the index procedure; * Lesions not suitable for stenting; * Lesions (defined as stenosis \> 75%) in the common or external iliac, common or superficial femoral and popliteal artery. However, intervention in TASC A and B lesions (max. 15cm) to restore adequate blood flow, in the same index procedure is allowed. This intervention must be prior to the treatment of the study lesion(s) and successful; * Lesions located at the bifurcation requiring treatment of both branches (1 in main branch and 1 in side branch); * Required stent placement across or within 1 cm of the knee joint; in an artery subject to external compression, or in an artery directly subject to movement of the ankle or knee joint; * Prior stent(s) within the target vessel(s); * Aneurysm in the SFA or popliteal artery; * Requiring popliteal arterial access; * Concomitant hepatic insufficiency, thrombophlebitis, deep venous thrombus, coagulation disorder or receiving immunosuppressant therapy; * Recent MI or stroke \< 30 days prior to the index procedure; * Coronary intervention \< 30 days prior to the index procedure; * Life expectancy less than 12 months; * Known or suspected active infection at the time of the index procedure, excluding an infection of a lower extremity wound of the target limb; * Impaired renal function (creatinine \> 2.5 mg/dl); * Known or suspected allergies or contraindications to aspirin, clopidogrel bisulfate (PlavixÒ) and ticlopidine (Ticlidâ), heparin, stainless steel or contrast agent; * The subject is currently taking Coumarin / Warfarin which, in the opinion of the investigator, interferes with the subject's participation in the study; * Any significant medical condition which, in the investigator's opinion, may interfere with the subject's optimal participation in the study; * The subject is currently participating in another investigational drug or device study that has not completed the primary endpoint or that clinically interferes with the endpoints of this study.