A Double-Blind Randomized Clinical Trial Comparing the Safety and Antiviral Activity of 48-week Clevudine and Adefovir Dipivoxil in HBeAg(-) Chronic Hepatitis B With Compensated Liver Function

Inclusion Criteria: * Patient is between 18 and 60 * Patient is documented to be HBsAg positive for \> 6 months. * Patient with compensated hepatic function. * Nucleoside treatment-naÃ-ve subjects of either gender * Patient is HBeAg negative. Patient is HBV DNA positive with DNA levels ≥ 1 x 10(5) copies/mL within 30 days of baseline. * Patient has ALT levels which are in the range of 2 x ULN and \< 10 X ULN * Patient who has not a history of ascites, variceal hemorrhage or hepatic encephalopathy. Exclusion Criteria * Patient is currently receiving antiviral or corticosteroid therapy. * Patients previously treated with lamivudine, adefovir, entecavir, telbivudine, clevudine, lobucavir, famciclovir or any other investigational nucleoside for HBV infection. * Previous treatment with interferon must have ended at least 6 months prior to the screening visit. * Treatment with nephrotoxic drugs, competitors of renal excretion, and/or hepatotoxic drugs within 2 months before study screening or during the study period * Subjects who are currently participating in another investigational study or has been taking any investigational drug within the last 4 weeks prior to screening visit. * Patient is coinfected with HCV, HDV or HIV. * Patient with following clinical evidence * Decompensated liver cirrhosis (Child class B,C: CPT score 7) or hepatocellular carcinoma * Significant gastrointestinal, renal, bronchopulmonary, neurological, cardiovascular, oncologic or allergic disease * Previous organ transplantation * Patient has a clinically relevant history of abuse of alcohol or drugs. * Patient is pregnant or breast-feeding. * Patient is unwilling to use an "effective" method of contraception during the study and for up to 3 months after the use of study drug ceases. * Patient has α-Fetoprotein more than 100ng/mL * Patient has Hemoglobin \<11g/dL (Male), 10g/dL (Female) or WBC count \< 3,500/mm3 (PMN\<1,500/mm3) or Platelet count \<50,000/mm3 * Patient has creatinine clearance less than 60mL/min as estimated by the following formula: (140-age in years) (body weight \[kg\])/(72) (serum creatinine \[mg/dL\]) \[Note: multiply estimates by 0.85 for women\]