The Effect of Nocturnal Haemodialysis on Arterial Stiffness

Melbourne Health30 enrolled

Overview

Arterial stiffness refers to the accumulation of extracellular deposits of matrix and calcium which reduce blood vessel compliance. Although there is growing evidence that increased arterial stiffness is associated with chronic kidney disease (CKD), its pathogenesis is unclear. Pulse wave velocity (PWV) and augmentation index (AIx) provide tools for estimating arterial stiffness, and therefore predicting cardiovascular morbidity and mortality. The aims of the study are: (1) compare the effects of nocturnal and conventional haemodialysis on arterial stiffness, and (2) examine the relationship between arterial stiffness and clinical and biochemical parameters.

Study Type

OBSERVATIONAL

Enrollment

Conditions

End Stage Renal Disease Arterial Stiffness

Interventions

Nocturnal HemodialysisPROCEDURE

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * adult dialysis patients * able to perform home nocturnal haemodialysis Exclusion Criteria: * age \< 18 and \> 80 years * any patient who is anticipating a live renal transplantation in forthcoming 12 months

Outcomes

Primary Outcomes

To purpose of this study is to evaluate the arterial stiffness in subjects who have undergone 12 months nocturnal haemodialysis.

Time frame: 12 months

Secondary Outcomes

To examine the relationship between arterial stiffness and clinical and biochemical parameters

Time frame: 12 months