Helium:Oxygen Noninvasive Positive Pressure Ventilation in Patients Exposed to Sulfur Mustard

Baqiyatallah Medical Sciences University23 enrolled

Overview

to assess the effect of Heliox with Noninvasive positive pressure ventilation to decrease dyspnea and improve physiologic and respiratory measures in patients with a previous exposure to Sulfur Mustard gas.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE

Enrollment

Conditions

Bronchiolitis Chronic Bronchitis

Interventions

helium:oxygen mixtureDRUG

Eligibility

Sex: MALEMin age: 38 YearsMax age: 59 Years

Medical Language ↔ Plain English

Inclusion Criteria: * exposure to sulfur mustard * worsening dyspnea during the last 10 days * respiratory rate of \>25/min * arterial pH\<7.35 * PaCO2 of \>50 mmHg * PaO2 of \<50 mmHg Exclusion Criteria: * recent pneumothorax (\<1 month) * severe respiratory failure or hemodynamic instability with forthcoming intubation * FIO2 of \<0.4 * impaired consciousness or absence of patient cooperation * facial lesions precluding NIPPV

Locations (1)

BMSU

Tehran, Tehran Province, Iran

Data from ClinicalTrials.gov

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