24 Hour IOP Lowering Efficacy of AL-3789

Alcon Research25 enrolled

Overview

The objective of this study was to describe the intraocular pressure-lowering efficacy of AL-3789 over a 24-hour period in patients with open-angle glaucoma compared to an untreated control. Patients received one treatment of AL-3789. Twenty-eight days after treatment, IOP was measured every 4 hours, beginning at 8 AM for 24 hours.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Open-angle Glaucoma

Interventions

AL-3789 Sterile SuspensionDRUG

Single administration by anterior juxtascleral depot

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of open-angle glaucoma and treated for at least 30 days prior to Screening Visit with a topical prostaglandin analog as monotherapy. * Other protocol-defined inclusion criteria may apply. Exclusion Criteria: * Pregnant, intend to become pregnant, breastfeeding. * Difference in IOP greater than 3 mm Hg between eyes at Screening Visit. * Any form of glaucoma other than open-angle glaucoma. * Other protocol-defined exclusion criteria may apply.

Locations (1)

Inglewood

Inglewood, California, United States

Outcomes

Primary Outcomes

Mean Intraocular Pressure (IOP)

Time frame: Day 28, Up to 24 hours

Data from ClinicalTrials.gov

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