This study will explore the effect of clopidogrel on coated-platelets in patients who are given a loading dose before diagnostic catheterization or percutaneous coronary intervention. We hypothesis that clopidogrel will reduce the percentage of platelets that are coated and therefore more hypercoagulable.
Platelet activity will be determined by light transmission aggregometry at baseline, after a 300 mg dose of clopidogrel and after the catheterization and/or angioplasty procedure. The change in the percentage of platelets that are coated platelets will be determined.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
27
All subjects will receive a 300 mg loading dose
VA Medical Center, 1F187
Oklahoma City, Oklahoma, United States
The Percentage of Coated Platelets After the Administration of Clopidogrel in Patients Undergoing Cardiac Catheterization and/or Angioplasty
The percentage of platelets that are collagen coated after the administration of clopidogrel.
Time frame: 24 hours after the administration of clopidotrel
The Percentage of Coated Platelets After Coronary Angiography and/or PCI
The percentage of coated platelets 24 hours after coronary angiography and/or PCI
Time frame: 6 hrs after procedure
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