Experiment in the test tube indicated that CP-945,598 becomes less soluble with increase of pH (less acidity). Changes in stomach acid levels may affect the solubility of CP-945,598, therefore, alters its availability in the blood. Omeprazole decreases acid levels in stomach. This study will compare the time course of drug concentrations in the body, safety, and tolerability of CP-945,598 given with and without omeprazole.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
28
Administration of CP-945,598 alone in period 1
Adminstration of CP-945,598 with omeprazole in period 2
Pfizer Investigational Site
Miami, Florida, United States
Measurement of drug concentrations in serum from blood samples collected at 4 days before given omeprazole, and after second single dose of CP-945,598 on days 1-6, 8.
Time frame: 1 day
Measurement of drug concentrations in serum from blood samples collected at various times after first single dose of CP-945,598 on days 1-6, 8, 15.
Time frame: 1 day
ECGs on the first and last day of the study
Time frame: 2 days
Saftey laboratory tests (chemistry, hematology, urinalysis) on the first and last day of the study
Time frame: 2 days
Vital signs (blood pressure, heart rate and respiratory rate) on the first and last day of the study
Time frame: 2 days
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