A Comparison of Sertraline Versus Venlafaxine XR in the Treatment of Major Depression

Change from baseline in the 17-item Hamilton-Depression Rating Scale (HAM-D) including response (≥50% reduction in HAM-D total score from baseline) and remission (HAM-D total score ≤7) rates.

Time frame: Weeks 1, 2, 3, 4, 6, 8, 9 and 10.

The 17-item Hamilton-Depression Rating Scale response rates at endpoint (week 8).

Time frame: Week 8

CGI response rate at endpoint (week 8).

Time frame: Week 8

Change from baseline in the CGI-Severity Scale (CGI-S).

Time frame: Weeks 1, 2, 3, 4, 6, 8, 9 and 10.

Change from baseline in the Hamilton Anxiety Scale (HAM-A).

Time frame: Weeks 1, 2, 3, 4, 6, 8, 9 and 10.

Change from baseline in the Endicott Work Productivity Scale (EWPS).

Time frame: Weeks 1, 8, 9, 10

Change from baseline in the Visual Analogue Scale (VAS) for Depression.

Time frame: Weeks 1, 2, 3, 4, 6, 8, 9 and 10.

Change from baseline in the Visual Analogue Scale (VAS) for Overall Assessment of Pain.

Time frame: Weeks 1, 2, 3, 4, 6, 8, 9 and 10.

Hamilton-Depression Rating Scale remission rates at endpoint (week 8).