To investigate the effects of a single dose of sildenafil (100 mg) or placebo on blood pressure and pulse rate in subjects taking doxazosin for benign prostatic hyperplasia (BPH). To investigate the pharmacokinetics of doxazosin when co-administered with sildenafil 100 mg, and to investigate the safety and toleration of sildenafil 100 mg when co-administered with doxazosin.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
20
placebo by mouth as a single dose
sildenafil 100 mg by mouth as a single dose
Pfizer Investigational Site
Laguna Woods, California, United States
Pfizer Investigational Site
Newport Beach, California, United States
Pharmacodynamic parameters of blood pressure and pulse rate
Time frame: immediately predose, 15, 30, and 45 minutes and 1, 1.5, 2, 2.5, 3, 4, 6, and 8 hours postdose
Blood samples for doxazosin pharmacokinetic parameters
Time frame: time 0 (pre-dose), and at 1, 2, 3, 4, 6, and 8 hours post-dose
Safety and toleration of simultaneously co-administering sildenafil and doxazosin.
Time frame: continuous
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