Helminth-induced Immunomodulation Therapy (HINT) in Relapsing-remitting Multiple Sclerosis

Inclusion Criteria: * McDonald Committee (2010) criteria for RRMS (MS) . * ambulatory patients with disability scores of EDSS 0.-5.0 * male or female subjects; ages 18-50 * diagnosis within three years of study entry, based on either a) two or more clinical attacks in the three years prior to entry or b) one attack within three years of entry, coupled with MRI evidence of dissemination in space and time by strict application of McDonald Committee MRI criteria * active MRI at entry, as evidenced by at least one gd+ enhancing lesion during screening * explicit refusal to be treated with conventional disease-modifying medications (DMT) for RRMS, after full discussion of the potential benefits and risks of these agents and after review of the National Multiple Sclerosis Advisory Statement DMT. * ability to provide written informed consent Exclusion Criteria: * patients who are unwilling or unable to give written informed consent or to follow the protocol successfully * allergy to Trichuris species * treatment with metronidazole (Flagyl) or other medications with anti-helminth effects (IB 5.7) * previous or anticipated treatment with FDA-approved or other experimental medications for RRMS * previous treatment with immunosuppressive therapy, cytotoxic chemotherapy, or lymphoid irradiation for any reason * insulin dependent diabetes mellitus * history of HIV-1, HTLV-1, viral hepatitis, or Lyme disease. * requirement for chronic, sustained aspirin or non-steroidal anti-inflammatory medications (e.g., use of more than 5-6 days per month for transient symptoms) * significant physical or mental disease which would preclude successful compliance and participation in the study or, in the opinion of the principal investigator, constitute a hazard, such that enrollment in the study would not be in the patient's best interest. * presence or history of cancer of any type (except successfully treated basal cell or squamous cell carcinoma of skin) * history of alcohol or drug abuse in last 12 months; chronic liver or biliary disease; AST or ALT determination greater than two times the upper limit of normal * any of the following laboratory abnormalities: serum creatinine \> 1.7 mg/DL, white blood count \< 3,500/mm3, lymphocyte count \< 800/mm3 * special subjects such as minor children, mentally disabled persons, or prisoners * any contraindication to MRI scanning, including significant claustrophobia or sensitivity to gadolinium contrast agent * pregnancy and lactation; women of childbearing potential must have a documented negative serum beta HCG pregnancy test at entry and during the study and must be willing to practice adequate birth control for the duration of the study * any MS attack or treatment with corticosteroid medication within 30 days of study entry (corticosteroids may be used during the study for MS relapses per the judgment of the treating physician, IB 5.7, IB 6.1.3) * immediate household or family contacts who are immunodeficient or immunosuppressed * history of parasitism or positive determination ova and parasite stool at screening