Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma With Portal Vein Tumor Thrombosis

Inclusion Criteria: * The diagnosis of HCC was based on the diagnostic criteria for HCC used by the European Association for the Study of the Liver (EASL) * Tumor size \>7 cm with a portal vein invasion, and the tumor was considered to be unresectable * No previous HCC directed treatment * Eastern Co-operative Group performance status 0-1 * Liver function: Child's A Exclusion Criteria: * Avascular tumor * Evidence of hepatic decompensation including ascites, gastrointestinal bleeding or hepatic encephalopathy * underlying serve cardiac or renal diseases * Known or suspected allergy to the investigational agent or any agent given in association with this trial * Diffuse-type HCC * For patients with main portal vein occlusion, no adequate collateral circulation around the occluded portal vein