Antimalarial Treatments for Clearing Low Density P. Falciparum and Its Impact on Malaria Transmission

Tropical Medicine Research Institute

Overview

The malaria parasite Plasmodium falciparum remains at sub-patent level throughout the dry season in areas of seasonal malaria transmission. Targeting this parasite reservoir before the transmission season could be a good strategy for malaria control. We are conducting a randomized double blind placebo controlled mass drug administration trial in eight village to clear the dry season low level parasitaemia with an ultimate aim of controlling malaria in eastern Sudan.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Conditions

Plasmodium Falciparum Asymptomatic Parataemia Sub Patent Parasitaemia

Interventions

Sulfadoxine / Pyrimethamine (SP) plus artesunate (AS)DRUG

Standard three day regimen

placebo tablet similar to active drug in shape and sizeDRUG

Dosage similar to active drug(standard three days regimen)

Eligibility

Sex: ALLMin age: 1 YearHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * All residents of the 8 villages Exclusion Criteria: * Pregnancy * History of allergy to sulfa drugs

Locations (1)

Tropical Medicine Research Institute

Khartoum, Khartoum State, Sudan

Outcomes

Primary Outcomes

Parsitaemia detected during the transmission season among dry season PCR negative persons in the intervention and control villages

Time frame: October to December 2006

Secondary Outcomes

1. Malaria prevalence during the transmission season 2. Frequency of mutation in drug resistance genes

Data from ClinicalTrials.gov

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