Study of the Safety and Efficacy of Adalimumab in Subjects with Moderate to Severe Chronic Plaque Psoriasis
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
137
40 mg eow through Week 12 followed by OL 40 mg eow through Week 48, permitted to escalate to weekly dosing upon relapse
40 mg weekly through Week 48 (OL Week 12 - 48)
80 mg W0, 40 mg eow through Week 12 followed by OL 40 mg eow through Week 48, permitted to escalate to weekly dosing upon relapse
Psoriasis Area and Severity Index
Time frame: Week 12
Adverse Events
Time frame: Throughout Study Participation
Psoriasis Area and Severity Index
Time frame: Week 0, 4, 8, 12, 16, 20, 24, 32, 40 and 48
DLQI, SF-36, Zung Depression Self-Rating Scale, EQ-5D, VAS
Time frame: Week 12, 24 and 48
Physician's Global Assessment
Time frame: Week 12, 16, 20, 24, 32, 40 and 48
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