Symbicort Onset of Action 1

AstraZeneca48 enrolled

Overview

The purpose of this study is to compare the early onset of effect of Symbicort compared to Advair Diskus and Ventolin in adults with asthma

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Asthma

Interventions

budesonide/formoterol (Symbicort)DRUG

fluticasone/salmeterol (Advair Diskus)DRUG

albuterol (Ventolin)DRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of asthma and baseline lung function test results as determined by protocol * Required and received asthma maintenance therapy within previous 4 weeks at doses determined by protocol Exclusion Criteria: * Severe asthma or asthma markedly affected by seasonal factors * Has required treatment with any non-inhaled corticosteroids within previous 4 weeks, has sensitivity to drugs specified in the protocol or requires treatment with beta-blockers

Outcomes

Primary Outcomes

FEV1 3 minutes post dose

Time frame: 4 assessments across 4 visits whilst on treatment (visits may be between 3 and 14 days apart)

Secondary Outcomes

12 hour serial FEV1

Time frame: 4 assessments across 4 visits whilst on treatment (visits may be between 3 and 14 days apart)

Patients perception of effect

Time frame: 4 assessments across 4 visits whilst on treatment (visits may be between 3 and 14 days apart)

Data from ClinicalTrials.gov

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