The Effect of Sedation on Eye Movements

N/ACompletedNCT00646646

University of Alabama at Birmingham65 enrolled

Overview

The purpose of this study is to determine whether sedation affects saccadic eye movements.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Saccadic Eye Movements

Interventions

propofolDRUG

sedative

dexmedetomidineDRUG

Sedative

MidazolamDRUG

sedative

saline placeboDRUG

Eligibility

Sex: ALLMin age: 19 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy, human volunteers, age 19-65. * American Society of Anesthesiology (ASA) class I-II for inclusion criteria Exclusion Criteria: * Pregnancy * Respiratory disease (severe asthma, emphysema) * Cardiac disease (coronary artery disease, congestive heart failure) * Symptomatic reflux disease * Advanced rheumatic disease involving cervical spine * Propofol or egg allergy * Neurological disease (stroke, intracranial processes) * Severe anemia

Locations (1)

General Clinical Research Center

Birmingham, Alabama, United States

Outcomes

Primary Outcomes

Dynamic Eye Movement Measures

Change in Eye Movements Parameters

Time frame: baseline to Sedation State (approx. 1 hr)

Data from ClinicalTrials.gov

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