Cotransplantation of Islet and Mesenchymal Stem Cell in Type 1 Diabetic Patients

Inclusion Criteria: * Male and female patients age 18 to 60 years of age * Ability to provide written informed consent * Manifest signs and symptoms that are severe enough to be incapacitating * Patients with poor diabetes control (HbA1c \> 7% but \< 12%) * Progressive diabetic complications Exclusion Criteria: * age \< 18 years or \> 60 years * diabetic history \< 5 years * BMI \> 27 * body weight \> 80 kg * exogenous insulin requirement \> 1 unit/kg/day * severe anemia (male \< 8 g/dl, female \< 7 g/dl) * low white blood cell count (\< 3000/dl) * liver dysfunction * Active infection including hepatitis B, hepatitis C, HIV, or TB * panel reactive antibody \> 20% * Any medical condition that, in the opinion of the investigator, will interfere with the safe completion of the trial