Insulin Sensitivity and Substrate Metabolism Before and After Treatment in Patients With Growth Hormone Deficiency

Inclusion Criteria: * Written informed consent * Must be of legal age and competent * Age: \>18 and \<60 years old * Presently diagnosed with growth hormone deficiency; if panhypopituitary, the patient must be sufficiently substituted in the other axis´s, for at least 3 months before inclusion in the study Exclusion Criteria: * Alcohol consumption \>21 units per week * Malignant disease * Pregnancy * Magnetic implants or material in the body * Claustrophobia * BMI \>30 * Heart disease (NYHA \>2) * Uncontrolled hypertension * Manifest diabetes mellitus * Change in medication, with any influence on glucose metabolism, 2 months prior to and until the end of the trial. Controls are matched on age, gender and BMI Inclusion Criteria: * Written informed consent * Must be of legal age and competent Exclusion Criteria: * Alcohol consumption \>21 units per week * Malignant disease * Pregnancy * Magnetic implants or material in the body * Claustrophobia * Heart disease (NYHA \>2) * Uncontrolled hypertension * Manifest diabetes mellitus * Change in medication, with any influence on glucose metabolism, 2 months prior to and until the end of the trial