Investigation of Analgesic and Anti-hyperalgesic Effect of Opioids in Experimental Pain

University of Aarhus22 enrolled

Overview

To compare the analgesic and anti-hyperalgesic effect of Buprenorphine and Fentanyl against experimental pain in skin, muscle and bone. The study will be performed with healthy volunteers.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

DOUBLE

Enrollment

Conditions

Pain

Interventions

BuprenorphineDRUG

Buprenorphine: 20microg/h

FentanylDRUG

Fentanyl: 25microg/h

PlaceboDRUG

Placebo: '5microg/h' (not active drug, it is just called '5microg/h')

Eligibility

Sex: MALEMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * written informed consent * men \> 18 years Exclusion Criteria: * women * known allergy against the investigated drugs * ongoing participation in other experiments or participation in other experiments 14 days before screening * previously pain or psychiatric conditions * simultaneously use of pain killers * alcohol * previously drug-addict or member of family with drug-addicts * chronic constipation * ileus * inflammatory bowel syndrome * abdominal surgery within the last three months

Locations (1)

Mech Sense, Department of Gastroenterology

Aalborg, Region Nordjyllan, Denmark

Outcomes

Primary Outcomes

Data will be electronically recorded or written directly in case report form. Outcome measure will be a subjective rating of the pain with a visual analogue scale.

Time frame: Continuously

Data from ClinicalTrials.gov

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