To evaluate the efficacy and safety of switching from Retrovir to Tenofovir or Abacavir in HIV-infected patients
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
40
Tenofovir disoproxil 245 mg oral tablet once daily
Abacavir 300 mg oral tablet twice daily
Aarhus University Hospital
Århus N, Denmark
Renal function measured by Cystatin-C and creatinine clearance
Time frame: Weeks 0, 4, 8, 12, 24, 24, 48, 96
Levels of renal tubule function markers in blood and urine
Time frame: Weeks 0, 12, 24, 48, 96
Bone mass assessed by DEXA
Time frame: Weeks 0, 24, 48, 96
Levels of bone turnover markers in blood and urine
Time frame: Weeks 0, 12, 24, 48, 96
Insulin resistance
Time frame: Weeks 0, 12, 24, 48, 96
Changes in body composition assessed by patient questionnaire and standardized examination by physician
Time frame: Weeks 0, 12, 24, 48, 96
Changes in subcutaneous adipose tissue assessed by DEXA
Time frame: Week 0, 24, 48, 96
Patients with viral load < 40 copies/ml
Time frame: Weeks 0, 4, 8, 12, 24, 48, 96
CD-4 cell count
Time frame: Weeks 0, 4, 8, 12, 24, 48, 96
Fasting triglycerides, HDL and LDL
Time frame: Weeks 0, 12, 24, 48, 96
Development of resistance mutations
Time frame: Weeks 0, 12, 24, 48, 96
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Development of adverse events and serious adverse events
Time frame: Weeks 0, 4, 8, 12, 24, 48, 96