The primary aim of the study is to determine the effect of reducing the number and/or dose of anti epileptic drugs on an individual's quality of life and seizure control in people with difficult to control epilepsy and who are on polytherapy. This is a randomised trial so children will be divided into two groups, with reduction of anti epileptic drugs in the first group (withdrawal group) and no change to their medications in the second (control group). Irrespective of the group the child is assigned to (withdrawal group or control group), we will ask parents to complete several questionnaires on 2 occasions: the first time will be immediately after the child enters the study (i.e. baseline assessment), and a second and last one will be 6 months after entering the study (i.e. follow-up assessment). These questionnaires aim to "quantify" aspects related with quality of life, AED side effects, seizure severity, and behaviour.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Masking
SINGLE
Enrollment
64
Reduction in anti-epileptic medications
No change in anti-epileptic treatment
Neurosciences Unit, UCL Institute of Child Health, The Wolfson Centre,
London, United Kingdom
Effect of reduction in anti-epileptic medications on quality of life in young people with intractable epilepsy
Time frame: 6 months
Identify other determinants of quality of life in this group of subjects
Time frame: 6 months
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