Safety and Efficacy Study of Isolagen TherapyTM in the Treatment of Nasolabial Fold Wrinkles

Inclusion Criteria: * Subject is at least 18 years of age * Level of severity of bilateral nasolabial fold wrinkles meeting severity criteria as per protocol * Level of subject dissatisfaction with both nasolabial fold wrinkles as per protocol * Ability to comply with the study requirements * Negative pregnancy test (Females) * Healthy post-auricular skin for biopsy Exclusion Criteria: * Excessive dermatochalasis of the treatment area * Inability to lessen the nasolabial fold wrinkles by physically spreading the area apart * Total area to be treated exceeds 20 cm in length * Physical attributes which may prevent assessment or treatment as judged by the evaluator * Use of an investigational product/procedure within 30 days prior to enrollment or plans for use during the study * Previous treatment with the sponsor's product * History of active autoimmune disease or organ transplantation * Diagnosis of cancer, unless successfully treated or in remission (basal cell carcinoma is excluded) * Active or chronic skin disease * Known genetic disorders affecting fibroblasts or collagen * Active systemic infection * Requires chronic antibiotic or steroidal therapy * Use of certain commercial products/procedures to the treatment area prior to study enrollment or plans for use during the study * Use of systemic agents that increase bleeding or clotting, or disorders equated with these effects * Known allergic reactions to agents used in preparation of treatment * Excessive exposure to sun without adequate sun protection