ThromboAblation in Acute Myocardial Infarction

Inclusion Criteria: Electrocardiographic inclusion criteria: (baseline 12-lead ECG recorded at 25 mm/second upon arrival at investigational center) * STEMI within 12 hours of symptom onset, with ≥ 2 mm ST segment elevation in two or more leads and minimum ≥ 3 mm ST segment elevation in one lead. Angiographic inclusion criteria after crossing with guidewire: * IRA is a native coronary artery; and, * Reference vessel diameter 2.5 - 4.0 mm; and, * TIMI 0 or 1 flow with any TIMI thrombus grade; or, * TIMI 2 or 3 flow with TIMI thrombus grade 3 or greater Exclusion Criteria: * Patient unwilling or unable to give informed consent * Previous MI in the distribution of the current IRA * Previous CABG * Contraindications to PCI * allergy(s) to intended study medications * contraindicated for stent implantation * Active bleeding or coagulopathy * Patient in cardiogenic shock (\<90mmHg SBP and/or requiring IABP or vasopressors) * Known left ventricular ejection fraction (EF) \<30% * Fibrinolytic administered before PCI * Renal insufficiency (creatinine \>2.0mg/dl) * Current vitamin K antagonist therapy or known INR \>1.5 * Known thrombocytopenia - platelets \<100,000 cell count * Patient has Left Bundle Branch Block (LBBB) or pacemaker rhythm * Known history of hemorrhagic stroke (CVA or TIA) \<2 years before screening * Known or suspected pregnancy * Current cancer disease * Comorbidity where survival is anticipated to be \<1 year. * No future patient cooperation expected * Patient is participating in another clinical study * Patient \<18 years of age