Molecular and Cellular Mechanisms of the In-stent-thrombosis

N/AWithdrawnNCT00652015

RWTH Aachen University

Overview

In-Stent-Thrombosis is a rare but serious complication after implantation of stents during PTCA.

In this prospective, open, not-randomized, controlled single-center pilot study 80 patients having had an in-stent-thrombosis (40 sub-acute thromboses (SAT), 40 late thromboses (LT)) and a control group of 80 patients having not developed a thrombosis will be compared. The aim of this study is the establishment of diagnostic markers vor prediction of SAT (detection of CD39- and CD73-activity, respectively)and of LT (EPC-number and function, respectively) correspondingly aiming at the early identification of patients with high risk for developing an in-stent-thrombosis.

Study Type

OBSERVATIONAL

Conditions

Patients With SAT or LT After Stent Implantation (PCI)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients having developed an SAT or LT after stent implantation using PTCA Exclusion Criteria: * instabel coronary heart diseases, * systemic autoimmune diseases, * rheumatic diseases, * tumors, * impaired kidney or liver function, * surgery within the last 3 months, * pregnant or lactating women

Locations (1)

RWTH University Hospital

Aachen, Germany

Outcomes

Primary Outcomes

The aim of this study is to establish diagnostic markers for prediction of SAT and LT, respectively, by identification of CD39 and CD73-activity and EPC-number and function, respectively.

Time frame: may 08 to may 2010

Data from ClinicalTrials.gov

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