Effects of MK7418 on Diuresis and Renal Function in Congestive Heart Failure Patients

Inclusion Criteria: * Be able to provide written informed consent, * Be a male or female at least 18 years of age, * Be hospitalized for fluid overload requiring IV diuretic therapy * History of use of diuretic therapy for CHF (including this admission), * Be admitted to the hospital within 36 hours of the mandatory dose of IV furosemide 40 mg at between 2000 and 2200 hour on Day -1 Exclusion Criteria: * Have had a myocardial infarction within 30 days prior to Day -1 * Be pregnant or breast-feeding * Have received intravascular contrast material within the preceding 14 days; or have acute contrast nephropathy * Have had implantation of an automated implanted cardiac defibrillator (AICD) or synchronization device within the preceding 7 days * Currently require mechanical ventilation, ultrafiltration, or hemodialysis, * Have symptomatic ventricular tachycardia * Be admitted for heart transplant surgery or have had a heart transplant, * Have any other concomitant life-threatening disease, * Have participated in a clinical trial of an investigational drug or device within 30 days before randomization * Have a positive urine pregnancy test (for women of child-bearing capacity) * Have an allergy to soybean oil and/or eggs