Progression of Carotid Artery Atheroma in Moderately Hypercholesterolemic Subjects

AstraZeneca200 enrolled

Overview

The purpose of this study is to examine the changes in the carotid artery when subjects receive high or low doses of rosuvastatin.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

200

Conditions

Carotid Artery Stenosis Hypercholesterolemia

Interventions

RosuvastatinDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Fasting blood low density lipoprotein cholesterol level as defined by the protocol * Diagnosed carotid arterial stenosis Exclusion Criteria: * The use of lipid lowering drugs or dietary supplements after Visit 1. * Heavy or total occlusion of the carotid artery or recent stroke * Uncontrolled hypertension, hypothyroidism, alcohol or drug abuse

Outcomes

Primary Outcomes

Changes in carotid wall volume as measured by MRI scan

Time frame: At 40 weeks and 104 weeks

Secondary Outcomes

Safety: adverse events & abnormal laboratory markers

Time frame: 2 weekly for first 4 weeks then 4 weekly

Other changes in the structure and composition of the carotid arterial wall as defined in the protocol.

Time frame: At 40 weeks and 104 weeks

Data from ClinicalTrials.gov

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