The primary purpose of this study is: 1. To compare dexmedetomidine with fentanyl in terms of intra-operative hemodynamics and post-operative analgesia. 2. To determine an analgesic dose response relationship for dexmedetomidine. 3. Compare recovery characteristics of dexmedetomidine to fentanyl.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
101
Fentanyl 1mcg/kg, Intravenous (IV)
Fentanyl 2mcg/kg, Intravenous (IV)
Dexmedetomidine, 2mcg/kg, Intravenous (IV)
Children's National Medical Center
Washington D.C., District of Columbia, United States
Time to First Morphine Dose
Total minutes from study medication administration to time of first morphine dose.
Time frame: up to 24 hours
Morphine Rescue
Total morphine administered in the Post Anesthesia Care Unit (PACU)
Time frame: up to 24 hours
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Dexmedetomidine, 4mcg/kg Intravenous (IV)