A Comparison of Olopatadine and Fluticasone in Patients With Allergic Conjunctivitis

Greiner, Jack V., OD DO PhD60 enrolled

Overview

To compare the clinical efficacy of olopatadine and fluticasone in a 3-week single center, double-masked, randomized, placebo controlled parallel treatment conjunctival allergen challenge (CAC) study in patients with allergic conjunctivitis

Study will evaluate the efficacy of nasal anti-allergic therapy compared to ocular anti-allergic therapy in the prevention of ocular allergic symptoms.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Conjunctivitis, Allergic

Interventions

OlopatadineDRUG

Ophthalmic solution

FluticasoneDRUG

Nasal spray

SalineDRUG

Nasal spray

Artificial tears

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * At least 18 years of age \& either sex, any race * Willing and able to follow all instructions and attend all study visits * Positive history of ocular allergies * Reproducible positive ocular allergic reaction induced by conjunctival allergen challenge Exclusion Criteria: * Have planned surgery during trial period * Female currently pregnant, planning a pregnancy, or lactating * Use of disallowed medications

Locations (1)

Ophthalmic Research Associates, Inc

North Andover, Massachusetts, United States

Outcomes

Primary Outcomes

Ocular itching

Time frame: Minutes following CAC

Secondary Outcomes

Ocular redness

Time frame: Minutes following CAC

Data from ClinicalTrials.gov

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