Safety and Immunogenicity of a New Serum-free DTaP-IPVvero Combination Vaccine

Inclusion Criteria: * The parents were informed about the trial and have signed the consent form * The subject is healthy * The subject has an age of 28 to 49 days at hepatitis B vaccination * The subject had a birth weight of ≥2500 g * The subject has received a hepatitis B vaccination at birth * The parents grant access to the subject's medical records * The parents are likely to comply with instructions Exclusion Criteria: * The subject suffers from a severe chronic disease * The subject has already been immunized with one or more doses of diphtheria, tetanus, pertussis, poliomyelitis, or Hib vaccines * The subject has a known allergy to one of the vaccine components or to any of the constituents of the vaccines, including Act-HIB® and hepatitis B vaccines * The subject has a history of diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B, or Hib infections * The subject has a known congenital or acquired immunodeficiency * The subject is in treatment with or has been in treatment with a product which is likely to modify the immune response (i.e. immunoglobulin, systemic corticosteroids, blood products, other vaccines) * The subject is participating in another clinical trial