Examining the Long-Term Risks of Oophorectomy

Parker, William H., M.D.32,175 enrolled

Overview

At the time of hysterectomy for benign disease, the overall health benefits of preserving ovarian function in a large population of women have not been established.

We are conducting a prospective, observational study of 32,175 women participants of the Nurse's Health Study who had a hysterectomy with or without removal of both ovaries. We are evaluating mortality and morbidity due to the following conditions: coronary heart disease, stroke, breast cancer, ovarian cancer, other cancer, hip fracture and death from all causes.

Study Type

OBSERVATIONAL

Enrollment

32,175

Conditions

Coronary Heart Disease Stroke Breast Cancer Ovarian Cancer Cancer Hip Fracture Death

Eligibility

Sex: FEMALEMin age: 30 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Women who had hysterectomies were classified into simple hysterectomy or hysterectomy with both ovaries removed. Exclusion Criteria: * Evidence of cancer, coronary heart disease (MI or Angina Pectoris), stroke, or hip fracture before entering the study were excluded. Cancer as an indication for hysterectomy also excluded. * Women reporting unilateral oophorectomy, unknown oophorectomy status, unknown age of hysterectomy, or those who had oophorectomy before hysterectomy were excluded.

Locations (1)

Parker, Rosenman, Rodi Gynecology Group

Santa Monica, California, United States

Outcomes

Primary Outcomes

mortality and morbidity due to the following conditions: coronary heart disease, stroke, breast cancer, ovarian cancer, other cancer, hip fracture and death from all causes.

Time frame: 28 years

Secondary Outcomes

The effect of postmenopausal hormone use on mortality and morbidity due to the following conditions: coronary heart disease, stroke, breast cancer, ovarian cancer, other cancer, hip fracture and death from all causes.

Time frame: 28 years

Data from ClinicalTrials.gov

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