The aim of the present study is to assess the effect of a high intake of industrially produced trans fatty acids for 16 weeks on abdominal obesity and risk markers of type 2 diabetes and heart disease in healthy, moderately overweight, postmenopausal women.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
52
Industrially produced trans fatty acid from soy bean oil (15 g/d for 16 weeks). The fat (a total of 25 g/d) will be baked into buns.
Control fat from sunflower oil, with 60% oleic acid (in total 25 g/d for 16 weeks). The fat will be baked into buns.
Department of Human Nutrition, University of Copenhagen
Frederiksberg, Copenhagen, Denmark
change in LDL-cholesterol/LDL-cholesterol ratio
Time frame: week 0, 8, 16 and 28
Change in Liver fat measured by MR-S
Time frame: week 0, 16 and 28
Change in Insulin sensitivity (ISI composite) from 3h OGTT
Time frame: week 0, 8, 16 and 28
Change in Waist circumference
Time frame: week 0, 8, 16 and 28
Change in Visceral adipose tissue measured by MR
Time frame: week 0, 16 and 28
Change in Intramuscular fat measured by MR-S (Psoas Major)
Time frame: week 0, 16 and 28
Change in Body fat percentage measured by DEXA
Time frame: week 0, 16 and 28
Change in 24h heart rate variability measured by Holter-monitoring
Time frame: week 0, 16 and 28
Changes in Cytokines in blood
Time frame: week 0, 8, 16 and 28
Changes in Cytokines in abdominal adipose tissue
Time frame: week 0, 16 and 28
Changes in Ceramide in abdominal adipose tissue
Time frame: week 0, 16 and 28
Changes in Metabolomic profile in blood and urine
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Time frame: week 0, 16 and 28