Study of Safety and Potential Efficacy of SYN117 in Cocaine Dependent Volunteers

Inclusion Criteria: * non treatment seeking cocaine dependent * English speaking * meet DSM IV TR criteria for cocaine dependence * pulse 50-90bpm * systolic BP 85-140 mmHg * diastolic BP 45-90 mmHg * essentially normal liver and kidney function blood tests * ECG normal * sign informed consent * negative urine pregnancy test at screening and admission Exclusion Criteria: * history or evidence of seizure disorder or brain injury * previous medically adverse reaction to cocaine, including loss of consciousness, chest pain or epileptic seizure * neurological disorders, organic brain disease, dementia * psychiatric disorders such as psychosis, schizophrenia, bipolar disorder, major depression * history of suicide attempts within past 3 months or suicidal ideation/plan * history of clinically significant heart disease or hypertension * family history in 1st degree relatives of early cardiovascular morbidity or mortality * untreated or unstable medical conditions * positive HIV test * pregnant or nursing * have asthma or are currently using alpha, beta agonists or theophylline or other sympathomimetics * test positive for other drugs of abuse with the exception of cocaine, cocaine metabolites or marijuana * any other illness, condition or use of psychotropic medications which preclude safe/successful completion of the study * currently on parole