Adrenal Insufficiency in Cirrhotics With Ascites. Effects of Hydrocortisone on Renal and Haemodynamic Function

University of Turin, Italy50 enrolled

Overview

Relative adrenal insufficiency (RAI) is an well known condition in patients with septic shock. Liver failure (including chronic liver failure)and sepsis are both characterized by hyperdynamic circulatory failure (with low arterial pressure) and high levels of pro-inflammatory cytokines. Hydrocortisone has been shown to have a beneficial effect on clinical outcome. The aim of this study is to evaluate the incidence of RAI in the different settings of ascites in cirrhosis and the usefulness of hydrocortisone in this context.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Cirrhosis With Ascites

Interventions

hydrocortisoneDRUG

50 mg/6 h per day

dextrose solution 5%DRUG

dextrose solution 5% 100 ml/6 h per day

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Cirrhosis with ascites, with or without hepatorenal syndrome Exclusion Criteria: * Age \< 18 and \> 75 years * Shock or bacterial infection present at the inclusion or during the previous week * Bleeding present at the inclusion or during the previous week * Multifocal HCC * Organic renal failure * Hearth or pulmonary failure

Locations (1)

San Giovanni Battista Hospital

Turin, Italy

Outcomes

Primary Outcomes

renal function

Time frame: 10 days

Central Contacts

Carlo Alessandria, MD

CONTACT

00390116335561 carloalessandria@libero.it

Monica Carello, MD

CONTACT

00390116335569 monicacarello@virgilio.it

Data from ClinicalTrials.gov

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