Tranexamic Acid Versus Placebo to Reduce Perioperative Bleeding After Major Hepatectomy

Inclusion Criteria: * Signature of the consent form * Patients with hepatic lesion needing a major hepatectomy (≥ 3 hepatic segments) Exclusion Criteria: * Absence of signature of the consent form * Patient with cirrhosis * Minor hepatectomy (\< 3 hepatic segments) * Hepatectomy associated with vascular resection * Contraindication of tranexamic acid : history of arterial or venous thrombosis , disseminated intravascular coagulation, severe renal insufficiency, history of epilepsies , intrathecal or intraventricular injection * Pregnant or lactation