Gene Expression Profiling in Skeletal Muscle of Healthy Subjects Treated With Ramipril

Inclusion Criteria: * Male * Healthy defined as absence of relevant disease * Caucasian * Aged 18-45 years * BMI: 18-28 kg/m2 * Signed informed consent * Blood pressure between 110/45 and \<140/90 (twice at screening) Exclusion Criteria: * History of renal artery stenosis * angioneurotic edema * psoriasis * relevant renal diseases * RR at screening \< 110/45 mmHg. * Diabetes, history of hypertension, RR \> 140/90 at screening, cardiovascular disease * Known Diabetes mellitus of parents * HIV or Hepatitis B/C positive virology * Allergy or hypersensitivity against ACE-inhibitors / ramipril or to xylocain * Contraindications against the use of the drug according to the SmPC, history of angioedema * Any drug intake 3 weeks prior to first study day * History of excessive bleeding tendency / hemophilia * Presence of relevant illness within the last 3 weeks * Suspected non-compliance with study instructions and life-style requirements * Alcohol or drug abuse * Blood/Plasma donation within 4 weeks prior to study day * Previous exposure to antihypertensive drugs, ACE-inhibitors, in particular ramipril * Current smoking (any quantity), (at least 6 months of non-smoking required)